The Revolutionary Key to Optimal Health and Energy – Part II

Posted on by colinchenery

Immunity

According to Dr. Hyman, Director of the Cleveland Clinic for Functional Medicine, our “gut flora can be causing cancer” as different microbiome imbalances can be related to different chronic conditions. Microbiome imbalance is being linked to bowel disorders, diabetes, neurological disorders, cardiovascular disease, cancer and autism – all the prominent chronic conditions and killers increasing steadily at this time.

Activation of our immune system activates a general and specific inflammatory response according to the signal compounds triggering it and this affects our whole body. It becomes a problem when it’s prolonged or even permanently switched on. So how it is, that microbes that are part of our ecology can regulate our body cells and our immune response, without instigating a major immune response themselves? Recent science has identified Toll-like receptors (TLR’s) that recognise patterns or molecular signatures of symbiotic microbiota molecules versus pathogenic derived molecules. Put simply, TLR’s help our body identify which communication is from friend or foe. When receptors for TLR’s are low, or there is inappropriate or unregulated activation of TLR’s, our immune system becomes highly sensitised and begins to attack everything in its own unique way. This along with other factors like Immunoglobulin (IgG) activity can be tied in with the huge increases in sensitivities and allergies occurring in many people mainly since the industrial age.

Toxins in our foods bond with proteins in the food, stressing and reducing our oral tolerance to chemical exposure. These toxin bound proteins also activate our immune response and general inflammation that is related to most of our modern chronic illnesses.

Improving our tolerance to foods and environment is about supporting diversity and balance of our microbiota. A diverse primarily plant-based diet with moderate and regular exposure to pathogens in our environment educates and refines the immune system of our gut.

Mild sicknesses, especially as we are growing up or from a change of environment, can be our natural way of developing our immunity and resilience. Centenarian’s around the world today have mostly had childhood sicknesses we now inoculate against, sterilise our environments and try and avoid at all costs. Children are being prevented with medications, domestic products and separation from the natural environment of having exposure to environmental microbes. Low risk illnesses like mild fevers and headaches are prevented or halted by medications so the immune response is halted from its full cycle to encode lifelong resilience. Overkill measures to protect our young and lack of outdoor environmental exposure is robbing the latest generation from gaining adaptable microbiota that practice, refine and remember successful immune responses to pathogenic stressors.

Sayer Ji (Natural Health Researcher and Educator) says that health and good immunity is not about ‘good’ and ‘bad’ bacteria and viruses but how they work together. He gives an example of the viral aspect of our microbiome which includes bacteriophages who help regulate certain bacteria. Viruses are a necessary source of certain genetic information looking for chromosomes to convey a horizontal transfer of often important genetic information to host cells. About 7% of our functional protein coding genome is retroviruses. So despite feared ones, like HIV, this category of microbiota is important to us. For example, retroviruses are responsible for neuroplastcicity that has helped our brains develop through evolution and remain functional and adaptive throughout our lifetime. Retroviruses were needed to evolve the placenta in pregnancy. Viruses like bacteriophages in our system are not necessarily bad.

Future health treatments for acute and chronic conditions will not only need to work with our microbiome ecology but do so on an individual level. This is a new area of development with many approaches of integrative therapies combining traditional and modern medicine. Mostly, mild treatments that help but don’t interfere with our full immune response will best assist healing and ongoing development of resilience. Lifestyle adjustments to diet, our activities and way we deal with stress to suit our own unique pathology and microbiome will become more specific and clear as science and holistic approaches to health become integrated.

Helping our microbiota for immunity:

  • Diverse locally grown foods are not only fresh but have their own helpful microbiome to provide useful information to our cellular and microbial compadres.
  • Wherever possible, eat organic foods not contaminated with sprays and chemical fertilisers and other chemical residues.
  • Playing and working or going barefoot in the dirt and natural environment exposure is an important part of our history, wellbeing as well as microbiome evolution and activation.

Environment

Chemicals in our environment (soil, air, living spaces, personal care and hygeine products, food and beverages) have been increasing exponentially. They impact our microbiome and gene expression. Additionally, deciding what microbes we allow and don’t allow in our living spaces, agricultural farming and elsewhere, without understanding microorganism ecologies, is causing great health issues for us and the environment.

Kiran Krishnan (Research Biologist) uses auto immune disease as an example, which can be triggered by medications or exposure to environmental factors like chemicals that “cause perturbations in the microbiome ecology that amplifies into a dysbiotic system we call disease”.

Epithelial cells line outer surfaces of organs, blood vessels and inner surfaces of cavities in internal organs (skin, lungs, gastrointestinal tract). Researchers and practitioners like Aristo Vojdani consider them one of the most important cell types in our immune system as they are the front line and channel of information between environmentally introduced compounds and microbes and the microbiota of our body and body cells. Environment and diet then impact their function and communication.

Apart from understanding microbial ecologies much more, many professionals are echoing traditional and complementary medicine views that we need to make friends with our symbiotic and pathogenic microbes in our bodies and environment. Exposure to pathogens has driven development of our resilience to disease and environmental change throughout evolution.

Using environmental factors to help your microbiota:

  • spend time outdoors in diverse ecosystems – research shows it impacts microbiome in the body and stress levels. The ocean, healthy rivers and forests provide this diversity in addition to outdoor time in your backyard or local parks.
  • eliminate chemicals in your home and household by finding chemical free products
  • growing your own food without chemicals and correct composting means diversifying microbial life in the soil that feeds the food you eat and contributes to better microbial diversity in your food.

Diet

Everyone has a unique microbiome make-up, however dietary fibre is a key part of the diet that affects type and amount of microbiota in everyone. It can only be broken down and fermented by enzymes from microbiota in the colon, one of the by-products being short chain fatty acids (SCFA). Apart from fibre enriching and supporting these microbiota, SCFA produced lowers pH of the colon limiting harmful bacteria like Clostridium difficile , and also stimulates healthy immune cell activity and helps maintain healthy glucose and cholesterol levels in the blood. Fruits, vegetables, beans and whole grains are generally good sources of prebiotic fibers.

According to Dr. Datis Kharrazian (Clinical Researcher, Functional Neurologist and Professor), when we change our diet, we change our microbiome balance and therefore our gene expression. Exposure to chemicals also changes our gene expression – when genes are activated, switched on or off. This is becoming a factor in many specialist areas of medical and health professions.

Dr. Michael Ash, D.O. (Research and Clinical Educator) considers the right nutrients as crucial to healthy communication between microbiota and mitochondria. He explains microbiota use nutrients to direct function and maintenance of mitochondria, while mitochondria produce metabolites in their activity that contribute to smooth healthy functioning microbiota. This loop of “dynamic dialogue is a new area of research”, its substrate being our food which also contains information from bacteria in the soil it grew in. This is a link to why eating locally grown fresh food is a big plus to helping our bodies adaptability in its local environment.

Foods that help our microbiome:

  • Probiotic foods provide live microbiome and include live-culture fermented foods like kefir and certain yoghurts with a good range and concentrated active culture (look for recommended brands), pickled vegetables and sauerkraut, miso, tempeh, kombucha tea and kimchi.
  • In Japan some fermented seaweeds and fermented soy beans called nato (also providing Vitamin K) are good.

Diet Actions:

  • Eat a diverse diet with plenty of wild and local plant based foods, preferably organically grown in local soils
  • utilise water purifiers to eliminate consumed chlorines and flouridation and exposure in showers and baths
  • Complex carbohydrates including tubers, root, fuits (separate from other foods) and vegetables provide pre-biotic fibre
  • Include probiotic fermented foods, wild plants and probiotic supplements including spore based live cultures
  • Our microbiome have circadian cycles related to our own circadian sleep and activity cycles. Intermittent fasting of 12 hours plus, which includes sleep time, is believed to increase microbiota diversity, strengthen our immune system and protect us against leaky gut [1,2]

Probiotic Supplementation

In line with the great strides in this new and game changing approach to health, probiotic and prebiotic supplements are big business these days, expected to surpass $65 Billion by 2024.

Dr. Allan Walker, Professor at the Harvard Medical and Public Health Schools believes probiotic supplementation “can be be most effective at both ends of the age spectrum, because that’s when your microbes aren’t as robust as they normally are”. However, due to the added weight of research providing understanding about the large impact of dietary and environmental factors, many health professionals are utilising probiotic supplementation to support adjustments in diet and environment for people of all ages. Microbiome issues and treatments can be based on microbiome testing and symptomatic indications of microbiome imbalance. Many symptoms of microbiome imbalance or gut infections can resemble other conditions because they are so fundamental to so many systems and functions in the body.

A probiotic supplementation should have a good range and concentration of active microbiota, which should include spore base microrganisms that are activated in the acidity of the stomach and breed in the lower gut. Not all microbiota are capable of passing the acidity of the stomach alive to get to the needed sites. Some probiotics that meet this, also provide some organic pre-biotic nutrition for the pro-biotic content such as this one. Many gut specialists have their own recommended products and a range of probiotic formulas for different overall types of body and microbiome constitutions.

For specific issues there is no probiotic to suit everyone, as our microbiome are so unique. However, effective and quality probiotics to date have proving to be of significant help to people who have low numbers or diversity of bacteria.

As an example of future possibilities, a recent 2018 study of probiotics, combined a probiotic blend with an Aryurvedic compound of amalaki, bibhitaki and haritaki medicinal fruits (called Triphala). The experiment looked at how gut microbiota composition can be impacted by probiotics to impact how foods are metabolised to lengthen life spans. The symbiotic formula (Triphala and probiotic) was tested based on research that indicated the combination would synergistically perform in enhancing microbiota activity while maintaining balance. Tests were done on fruit flies who have about 70% similarity in biochemical pathways and the promising results produced an impressive 60% increase in the lifespan of flies fed with the symbiotic formula. While humans are not expected to have as dramatic a result there is much optimism about such formulas promoting longer life and good health with possible applications to be tested with disorders like diabetes, obesity, neuro-degeneration, chronic inflammation, depression, irritable bowel syndrome and some cancers [3].

References – Part II

  1. V.D. Longo, Satchidananda Panda, Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan, Science Direct 2016 https://doi.org/10.1016/j.cmet.2016.06.001
  2. C.A. Thaiss, D. Zeevi, et al., A Day in the life of the meta-organism: diurnal rhythms of the intestinal microbiome and its host, published online: 22 April 2015 https://doi.org/10.1080/19490976.2015.1016690
  3. Westfall, S., et al. Longevity extension in Drosophila through gut-brain communication, Scientific Reports (2018). DOI: 10.1038/s41598-018-25382-z

Other Sources:

Many of the experts cited here have been quoted from the online series The Human Longevity Project at https://humanlongevityfilm.com/ and include:

  • Dr. Mark Hyman (Director at Cleleveland Clinic Center for Functional Medicine)
  • Kiran Krishnan (Research Biologist)
  • Aristo Vojdani PHD, MSC (Professor of Neuroimmunology)
  • Sayer Ji (Natural Health Researcher and Educator)
  • Dr. Datis Kharrazian (Clinical Researcher, Functional Neurologist and Professor)
  • Dr. Michael Ash, D.O. (Research and Clinical Educator)
  • Dr. Allan Walker, Professor at the Harvard Medical School and Harvard T.H. Chan School of Public Health

Photo credit: IBM Research on Visual hunt / CC BY-ND (quote added)

Important Tips on Vagal Toning for Complete Health

Posted on by colinchenery

Much about good health and a healthy long life is now being linked to the ‘tone’ of the sympathetic and parasympathetic nervous systems. Because the sympathetic nervous system which invokes ‘flight or fight’ response is also commonly over-activated in stressful and fast paced living, it is more important than ever to tone the parasympathetic system for mind and body, in addition to high activity exercise.

Toning the parasympathetic system assists in repair and rebuilding to all cells and tissues in the body, quicker recovery and shifts into relaxation, lowering blood pressure, and helping recovery from adrenal fatigue. Having both the parasympathetic and sympathetic nervous systems toned and balanced is important for mitochondrial functioning, lowering inflammation, regulating hunger and hormonal balance and boosting immunity.

The importance of regulation and health of microbiome in the body is tied in with the parasympathetic system health. Much is now being found out about the critical role bacteria plays for health regulation in the body and immunity. Consider the mass of our bacteria is greater than our own body cells, and our body cells contain 3000 genes while there are 2.2 million genes in the DNA of our bacteria with a cross-over of information between our body and brain and these critical bacteria. Microbiome, along with mitochondrial functioning will be covered in another article, but these are now considered two key factors in energy production, disease prevention, brain health and long term anti-ageing for healthy longevity and are also linked up with the tone and functioning of the vagus nerve.

The Vagus Nerve

A key component to the parasympathetic system that is now taking centre stage amongst many practitioners of health and healthy lifestyles is the vagus nerve. This is a two-way highway of energy and information between body and brain. Taking its name from the latin word for “wandering”, it is the tenth and biggest cranial nerve extending directly from the medulla (brain stem) to most of the body. It affects facial muscles and eyes when we relax and smile, connecting to our digestive system from our throat to all digestive organs, and connects with our heart and lungs. It’s connection to the digestive organs of the liver and kidneys mean it is not only impacting our digestion and metabolism but also detoxification and elimination of waste and by-products of what we eat, breath and put our bodies through with stress and over – or under-activity. A toned nervous system supports stability in mood, memory, and overall brain health. So there are many systems of rejuvenation and body functioning that the vagus nerve impacts, to indicate it is a key factor in a holistic approach to health.

Here are some conditions and health factors that are associated with the level of tone of the vagus nerve:

  • the bodies inflammatory response: many chronic as well as acute conditions are now understood to be associated with inflammation
  • Repair and cell growth of brain cells and assisting in memory
  • Depression and anxiety
  • Immunity including the level of T-cell and killer cell response to disease and body repair
  • Various addictions and compulsive disorders
  • Mental health disorders
  • Chronic Fatigue Syndrome

Vagal tone can be indicated through the many bodily systems it affects and is generally measured directly through combined testing of heart and breathing rates, as well as heart rate variability (HRV) which is associated with the adaptability of your body to changes in external and internal conditions. HRV and vagal tone are closely correlated to one another – if one is functioning highly, then so is the other.

Vagal Toning

How do you ensure that you have good vagal toning? The same key factors recognised for vagal toning match most of the key factors recognised for acquiring and maintaining good health and healthy longevity! Here they are:

  1. Cold Exposure

    Acute cold exposure is shown by many researchers to activate the vagus nerve. It is a key factor to the Wim Hof Method which uses exposure to cold and breathing techniques for activating health and vitality. Just using ice cold water on the face is enough, or incorporating a brief cold shower into your usual shower routine. Within two weeks or less, most people notice a decline in the deep inhale or breath hold reaction to sudden cold, and notice a more relaxed response to the sudden exposure to cold. This indicates neural adaptation and vagal toning.

    Vagus nerve stimulation increases parasympathetic activity throughout the body and stimulates digestion and metabolism. Our bodies evolved to rely on such stimulation and environmental stressors like cold, which we now lack in the modern world of controlled environments. It only takes a little to strengthen and activate important functions of resilience towards these stressors which in turn enhances our resilience to stressors in general.

  2. Deep Slow Breathing

    The direct correlation between breath and heart rate (as well as HRV) and the vagus nerve that modulate or regulates them, means conscious breathing is also a quick, powerful and easy way to activate the vagus nerve. Research shows benefits to blood pressure and hypertension with breathing exercises alone. High breathing rates activate the sympathetic nervous system while slow deep breathing activates the parasympathetic nervous system and so helps autonomic functions like the respiratory and cardio-vascular systems to go into repair and recovery.

The most basic exercise is to do 1-3 minutes of inhaling for a count of four, holding for a count of four, exhaling for a count of four, then waiting for another count of four before repeating. Doing this when your getting stressed at home or office, car or shopping mall will help brain function, effectiveness and comfortability go up and stress levels go down by releasing calming chemicals to feed your brain rather than stress chemicals to your muscles.

  1. Synchronised Movement and Breath like Yoga, Tai Chi and Xigong

    Just like what is said above, breathing itself activates the vagus nerve. Breathing associated with movement that stretches fascial tissue, muscles and joints while opening up energy channels have been found to be very effective in producing calming neurotransmitters like GABA in the brain and body. The traditional forms of yoga that incorporate activity with regular intermittent relaxation in poses like ‘sivasana’ can produce deeper and deeper levels of relaxation and endocrine production for relaxation and mood elevation. Also, particularly activating for the vagus nerve are relaxed movements with deep breathing that are expanding the thoracic (chest) region, inversions (legs up against a wall, various head stands, hand stands and shoulder stands) as well as sustained twisting postures with spine straight and chest out.

    In addition to those who have discovered the great benefits of yoga and Tai Chi, these types of activities are being used more and more by high performance athletes to assist in recovery and improved resilience to ongoing physical demands while the same holds true for resilience, good health and mood elevation throughout the challenges of life.

  2. Meditation and Conscious Presence

    After nearly fifty years of scientific studies, vast amounts of research has now been done on various types of meditation and the many benefits. In addition to increased vagal tone, positive emotions and thinking, and feelings of goodwill, studies done in schools and universities also show increases in concentration and brain functioning, and decreases in mental disorders and violent interactions.

    Meditation as well as general practice of conscious presence trains the mind to function effectively at brain frequencies that reduce sympathetic ‘fight or flight’ stress responses and increases vagal modulation. Greater insight, creativity, calm awareness, appreciation and mood elevation are among the many other benefits are confirmed in studies. So is the ability to respond and act in situations with less or little stress and adrenaline involved through this type of mind training.

  3. Exercise or High Intensity Activity

Exercise also has many studies showing it to be an effective way to increase the brains growth hormone, stimulate human growth hormone production during deep sleep, increase important receptor sites for mitochondrial functioning in and on cells, and help reverse cognitive decline and other aspects of ageing.

Exercise as a great stimulator of the vagus nerve may explain some of these benefits.

Walking, weight bearing exercise and high intensity training are all good. Weight bearing is especially good for reversing decline in bone and muscle density and decline of certain hormone levels in the body associated with ageing. So is interval training, in addition to being a very time effective way to build fitness. For interval training, try 10-30 minutes of walking, jogging or cycling 3-4 times a week, with periodic 1-2 minute bursts at maximum pace during each session.

  1. Probiotics and Dietary Factors

    There are many new studies in the last ten years indicating strong associations between brain function and immunity as well as vagal tone with microbiome (micro-organisms in the body) – especially bacteria in the gut.

    In addition, dietary factors like essential fatty acids (fats the body can’t make itself like Omega-3 and -6) are critical for cellular integrity, brain and mental health and nerve function. This includes vagal tone, which may be also why dietary fatty acids can help reduce heart rate and increase heart rate variability. A great source of these are in certain fish oils (organically farmed or wild-caught salmon are an example or Australian northern river fish like Barramundi are rich in Omega-3 and Omega-6 oils).

    Zinc is also a key dietary mineral for vagus nerve stimulation and preventing or improving various certain brain function disorders, mental health and anxiety. Good food sources include oysters, pumpkin seeds, cashews, mushrooms, spinach and grass-fed beef for meat eaters.

  2. Intermittent Fasting

Many health benefits are being documented and studied now on fasting, with more attention lately on short-term intermittent fasting. This also is being shown to help improve brain function and growth hormones, mitochondrial function, brain ‘fog’ and cognitive issues. Fasting and caloric restriction is also being associated with increased HRV again indicating vagal tone improvement.

The ideal is to not eat at least two hours before bed, which also improves sleep patterns. Best results are if most days, people can have a 12 to 16 hour window of not eating between dinner and breakfast. Immunity increases, detoxification and cellular cleansing (cellular death – apoptosis- and cellular reproduction cycles) are also stimulated. The 16 hour window of fasting (with an 8 hour window of healthy eating) is a great way to sustainably lose weight. The 12 hour fasting window is great for general health and weight maintenance (helping to keep down accumulation of unhealthy fat). Once every week, fortnight or month also try a 36 hour fast by only having fluids during one day to reset the body, stimulate many healing processes, increase resilience to disease, environmental and other stressors.

  1. The Power of the Voice

    Vagus nerve expert, Dr. Stephen Porges established Polyvagal Theory. He talks about the hard wiring in our evolution towards flight-or-fight stimulation including response to social communication which encompasses verbal and body language, vocal tone and non-verbal cues.

    A soothing voice for adults and children in gentle, slow and rhythmic tones coaxes the brain into a relaxed state faster and activates the parasympathetic nervous system, including the vagal nerve. This is true whether you are the speaker or listener. While the voice is powerful and effective for adults, it is great for young children for whom a modulated and calm voice is powerful for vagal and parasympathetic development and toning during years where much neural programming or conditioning is happening. It is powerful also for babies (especially combined with skin-to-skin contact) and can be utilised regularly and daily in combination with other approaches mentioned in this article.

    Singing, humming, chanting and even gargling all stimulate the vagus nerve which connects to the vocal chords and muscles in the throat. These all are shown to also increase the hallmark sign of vagal toning which is increase of heart rate variability.

  2. Social Lifestyle and Laughter

    Quite a few studies on social factors have linked healthy, active and supportive social life with healthy longevity as well as recovery from illness or trauma. In addition, laughter has been shown to be strongly related to good health as well as healing and recovery. Both socialising and laughter reduce cortisol and other stress related hormones, stimulate the vagus nerve and HRV while improving mood and happy hormone production. Unfortunately for some, excessive or heavy alcohol consumption is somewhat counter effective, so moderating consumption while having as much fun and shared frivolity is great for one and all!

  3. Acupuncture and Massage

Both acupuncture and massage stimulate the vagus nerve, increasing its activity and tone. Specific points and areas like the sole of the foot (reflexology), auricular (ear) acupuncture, points along the side of the neck (near the carotid artery) are especially good for this. They are also effective spots to assist people coming off anti-depressants and other psychiatric medication, assist people with neurodegenerative diseases, as well as general stress related issues.

In closing …. my intention is not to write a scientific paper here. There are many references related to these ten points above which be can provided for specific points on request. Many supporting studies can be found through a simple online search on any term or specific topic. Much is common sense and there’s enough information here to help you take control of stress levels and steer your way into better mind and body health. Having all points above as part of your lifestyle will help disease prevention, increased resilience, promote total health while increasing enjoyment and quality of life.